Clinical Scientist in
About Me
A clinical respiratory physiologist with a strong interest in obstructive lung disease and chronic cough. A focus on asthma and the diagnosis of asthma and objectively monitoring benefits to therapeutic interventions documenting optimal benefits to therapy in a wide variety of asthma severities. Passionate about respiratory measurement and using the best objective measures for effective diagnosis and monitoring. There is a great need to take good technological advances into the clinic.
Education
at the University of New South Wales, Kensington, NSW, Australia Double Major: Physiology & Pharmacology, Molecular Biology & Biochemistry.
1997
at University of Sydney; 1st Class Honors equivalent (Mark; 85)
at University of Sydney, under the supervision of Professor J.P Seale & Dr S.D Anderson. PhD Thesis Title: “Osmotic challenge in asthma using dry power of mannitol”. Accepted June 19th, 2001.
What I do
Fortunate to start training at a Center of Excellence, Royal Prince Alfred Hospital in Sydney under the supervision of Dr Sandra D. Anderson, I was pivotal in the development of the mannitol bronchial provocation test (Aridol/Osmohale) that has registration with leading regulatory authorities (e.g., FDA, TGA, EMA).
Following receiving my PhD in 2001 from the University of Sydney with my thesis titled “Osmotic challenge in asthma using a dry powder of mannitol” I played a key role in the technology transfer of this technology to Pharmaxis leading to the first regulatory authority guided Phase 3 study of a bronchial provocation test.
Diagnosis & monitoring of asthma
Focus on understanding the presensence and severity of steroid sensitive pathology contributing to the key feature of asthma, airway hyperresponsiveness (AHR). Assessment of the abolition of AHR to document resmission of pathophysiology.
Clinical Research
Active in further investigation into the mechanisms and treatment responses in both asthma and exercise-induced bronchoconstriction, with an emerging interest in assessment and treatment of chronic cough.
Suitable Subheading
Teaching both theory and practical application of lung function testing used to assess lung disease, with an expertise in tests for airway hyperresponsiveness and biomarkers. Education of pharmacology used in airway disease. Clinical respiratory laboratory creation and clinical trial design.
Professional Experience
John D. Brannan
Clinical Scientist
From April 1995 to July 2005
➥ Research Fellow employed by Dr Sandra D. Anderson in the Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, Australia; on grants from the National Health and Medical Research Council of Australia & funds awarded from the Royal Prince Alfred Research Prize.
From August 2005 to 2007
➥ Post Graduate Research Fellow employed by Professor Paul M. O’Byrne in the Asthma Research Unit, Firestone Institute of Respiratory Health, St Joseph’s Healthcare, Hamilton, Ontario, Canada; on the Asthma Foundation of New South Wales, Martin Hardie TravelingFellowship.
From August 2007 to February 2009
➥ Senior Research Fellow employed by Professor Paul M. O’Byrne and Assoc Professor Parameswaran Nair in the Asthma Research Unit, Firestone Institute of Respiratory Health, St Joseph’s Healthcare, Hamilton, Ontario,Canada; funded by Department of Medicine, McMaster University
April 1995 to present
➥ Pivotal in the development of dry powder mannitol for bronchial provocation to identify airway hyperresponsiveness and worldexpert on this methodology. Licensed to Pharmaxis Ltd., Australia, Aridol™ or Osmohale™ is now registered in 26 countries worldwide, including Australia and the European Union and the United States.
March 2009 to March 2012
➥ Honorary Visiting Fellow, Department of Respiratory & Sleep Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
April 2010 to April 2011
➥ Postdoctoral Research Associate, Advanced Drug Delivery Group, Faculty of Pharmacy, University of Sydney, NSW, Australia.
April 2011 to March 2012
➥ Senior Hospital Scientist, Intensive Care Services, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
March 2012 to present
➥ Hospital Scientist, Respiratory Function Laboratory, Department of Respiratory & Sleep Medicine, Westmead Hospital, NSW, Australia.
September 2014 to December 2014
➥ Senior Hospital Scientist, Respiratory Function Laboratory, Department of Respiratory & Sleep Medicine, Westmead Hospital, NSW, Australia.
September 2014 to 2016
➥ Associate Investigator, Ludwig Engel Centre for Respiratory Research, Westmead Millennium Institute, Westmead NSW, Australia.
January 2015 to October 2023
➥ Scientific Director, Department of Respiratory & Sleep Medicine, John Hunter Hospital, New Lambton, NSW, Australia.
October 2018 to present
➥ Scientific Director, Maitland Pulmonary Function Laboratory, Hunter Respiratory & Sleep Clinic, East Maitland, NSW, Australia.
June 2020 to present
➥ Conjoint Associate Professor, School of Medicine and Public Health, University of Newcastle, NSW, Australia.
Fellowships & Research Grants
2004
2004 Asthma Foundation of New South Wales, Martin Hardie Traveling Postdoctoral Fellowship (Funding for post-doctoral period at McMaster University from August 2005 to August 2007)
2008
2008 General Practice Education & Training Australia (GPET) grant for pilot clinical study; “A pilot study into the feasibility and acceptability of Outcome and Goal orientated monitoring of Inhaled corticosteroids in asthma within the general practice context using indirect airway hyper-responsiveness challenge testing to achieve rapid disease control” (OGOMIA) (Collaborators: Dr James Turton, Dr Nicholas Glasgow, Australian National University, Canberra)
2012
2012 Australian & New Zealand Society of Respiratory Scientists; “Monitoring inhaled corticosteroid efficacy in persons with asthma in pulmonary function laboratories” (Collaborators: Mr Peter Briffa, Dr Evangelia Daviskas, RPAH)
2016
2016 John Hunter Hospital Charitable Trust; “Nocturnal asthma, sleep and mast cell activation” (Collaborators: Dr Shyamala Pradeepan)
2017
2017 University of Newcastle equipment grant (Collaborators: Ms Ginger Chu, Dr Michael Hensley, Dr Peter Gibson)
2018
2018 Australian & New Zealand Society of Respiratory Scientists; “Cough sensitivity to inhaled mannitol to identify cough hypersensitivity syndrome” (Collaborators: Ms Clair Lake, Dr K Wong, Dr H Koskela)
2021
2021 GSK Research title: Monitoring intermittent vs Regular inhaled corticosteroids in asthma: MIRSA: (Collaborators: Dr Max Plank, Dr Chris Grainge)
Awards
The following awards and honors reflect years of dedication to research, education, and advancing respiratory medicine throughout an academic career.
1994/95
: Asthma Foundation Summer Scholarship
1997
: Australian and New Zealand Society of Respiratory Scientists Travel Scholarship
1999
: The Australian Lung Foundation/Mallinckrodt Travel Scholarship
1999
: The Royal Prince Alfred Hospital D.K Baird Bicentennial Traveling Fellowship
1999
: Asthma Foundation of NSW Research Award
2002
: Nominated by Rothschild’s Bioscience and short-listed for the Australian Federal Science Ministers Life Scientist of the Year award.
2003
: Best Oral Presentation at the Australian & New Zealand Society of Respiratory Science Meeting, Cairns, QLD.
2004
: International Travel Scholarship recipient for the 60th AAAAI Annual Meeting, San Francisco.
2005
: Thoracic Society of Australia and New Zealand Annual Meeting Poster prize for abstract: Bronchial provocation using inhaled mannitol – A phase 3 trial of adult & pediatric asthmatics and non-asthmatics. Respirology 2005 10: A1
2006
: AllerGen NCE Inc. Poster presentation competition (3rd place) for “The effect of treatment on recovery of FEV1 to baseline after a mannitol challenge: A phase 3 study” at the First Annual AllerGen Network Trainee Symposium. Toronto, Ontario, Canada
2009
: National Asthma Campaign Poster Prize, “Feasibility and acceptability of using bronchial hyperresponsiveness to manage asthma in primary care: A pilot study”. The Conference for General Practice, Perth, WA.
2014
: Tracy Robinson Award for Teaching Excellence: Ludwig Engel Centre for Respiratory Research.
2018
: Best Oral Presentation at the Australian & New Zealand Society of Respiratory Science Meeting, Adelaide, SA.
Looking Ahead
Building on past achievements while continuing
to inspire research, innovation, and learning.
Invitations to speak at International Meetings & Institutions
• American Thoracic Society (ATS), USA
• 2005 ATS Meeting – Postgraduate Symposium PG-13: Pulmonary
Function Laboratory: Guidelines & Controversies: Choosing among
bronchial provocation tests
• 2011 ATS Meeting (WS4): Understanding & Managing Exercise
Induced Bronchoconstriction: Airway provocation to establish a
diagnosis of exercise-induced bronchoconstriction
• American College of Asthma, Allergy and Immunology (ACAAI), USA
• 2006 Symposium: Understanding, Diagnosing and Treating Exercise
Induced Asthma – Challenge Testing: Comparing Techniques
• American College of Sports Medicine (ACSM), USA
• 2011 Meeting: New Insights into Airway Function During and After
Exercise in the Asthmatic Athlete
• Pediatric Allergy & Immunology Conferences, Kuwait
• 2010: Use of In Vivo and In Vitro Diagnostic Tests in Asthma
• 2010: Tolerance to Beta2 Agonists: Is It Clinically Relevant?
• 2014: Effects of Pharmacotherapy on Inhibiting Exercise-Induced
Bronchoconstriction in Adults and Children
• 2014: Objective Assessment in Monitoring Inhaled Corticosteroid
Treatment
• 2014: Protocols for Bronchial Hyperresponsiveness
• Thoracic Society of Australia & New Zealand (TSANZ)
• 2015: Bronchoprovocation Challenges: Which Test for Which Patient?
• 2015: Laboratory Assessment of Airway Disease
• Thai Asthma Council
• 2024: Beyond Spirometry for an Asthma Diagnosis
• 2025: The Challenge of Exercise-Induced Bronchoconstriction
• McPherson Lectureship
• 2008: Use of Inhaled Mannitol in Diagnosis and Therapy of
Respiratory, DiseaseUniversity of Saskatoon, Canada
• Advances in Pediatric Allergy & Asthma Conference
• 2010: Keynote Presentation:
Use of In Vivo and In Vitro Diagnostic Tests in Asthma, Kuwait
• Ganshorn Academy
• 2023: The Value of Objective Measurement in Lung Disease, Thailand
• University of Saskatoon, Canada
• 2008: McPherson Lectureship:
Use of Inhaled Mannitol in Diagnosis and Therapy of Respiratory Disease
• McMaster University & St Joseph’s Healthcare, Canada
• 2009: Inhalation Challenge for Airway Disease Symposium: Airway
Hyperresponsiveness as a Monitor for Asthma Control
• Thammasat University, Thailand
• 2024: Chronic Cough Management
• McMaster University & St Joseph’s Healthcare, Canada
• 2009: Airway Hyperresponsiveness as a Monitor for Asthma Control
• Mayo Clinic, USA
• 2019 Invited Speaking Engagement on behalf of Methapharm Inc.
• Cleveland Clinic, USA
• 2019 Invited Speaking Engagement on behalf of Methapharm Inc.
• Guangdong Respiratory Health Society, China
• 2025: Airway Hyperresponsiveness: Mechanisms of Action for
Assessment and Monitoring of Inhaled Corticosteroids
• Thai Asthma Council, Thailand
• 2024: Beyond Spirometry for an Asthma Diagnosis
• 2025: The Challenge of Exercise-Induced Bronchoconstriction
Invitations to speak at National Meetings
• NSW Respiratory Education Meeting of the Thoracic Society of Australia
(2010) : Clinical utility of tests for bronchial hyperresponsiveness in diagnosing and monitoring asthma therapy
• Thoracic Society of Australia and New Zealand (2013) : Inhalation
challenge testing
• Australian & New Zealand Society of Respiratory Scientists (2011) : An
update on inhaled mannitol (Aridol™) as a test for BHR
• Australian & New Zealand Society of Respiratory Scientists (2017) :
Methods to assess airway hyperresponsiveness
• Children’s Health Queensland Hospital and Health Sciences (2025) :
Insights from respiratory function testing
• National Rugby League Pre-Grand Final Conference (2010) : Methods of identifying exercise-induced bronchoconstriction and their role in
optimizing management
• Australian & New Zealand Society of Respiratory Scientists (2012) : The role of exercise testing in asthma in 2012
• Royal Australian Navy Dive Medical Course (2009–2013) : Assessment of
airways in diving
• Thoracic Society of Australia and New Zealand (2013) : Inhalation challenge testing
• Thoracic Society of Australia & New Zealand / ANZSRS Masterclass (2016)
: Mechanisms of action of bronchial provocation tests
• Australian & New Zealand Society of Respiratory Scientists (2017) : Methods to assess airway hyperresponsiveness
• Boehringer Ingelheim (2016) : Airways: Dry Powder Devices
• GlaxoSmithKline Workshop (2017) : Theory behind spirometry and
practical spirometry workshop
• GlaxoSmithKline RESCO Conference (2022) : Dry powder inhalers: From evolution to revolution
• GlaxoSmithKline RESCO Conference (2022) : Scientific rationale and
complimentary effects of LAMA, LABA and ICS in asthma
Professional Memberships
•1996 to present: Australian and New Zealand Society of Respiratory Science
•2010 to 2011: Australian Society of Medical Research
•2013 to 2018: Thoracic Society of Australia and New Zealand
•2017 to present: European Respiratory Society
Further Education
•1995 Introductory Bio-statistics, Faculty of Medicine, University of Sydney
•2001 (November 5-7): European COPD School, Ghent, Belgium
•2008 (July 8-9): RogenSi Presentation Skills Program, Toronto, Canada
•2016 (October 20-22): Exercise Testing and Interpretation, Harbor-UCLA Medical Centre, Los Angeles, United States
•2018 (November 27-29): National Association of Testing Authorities, Australia; Quality management in the laboratory, Sydney, Australia.
•2019 (February 6-7): National Association of Testing Authorities, Australia; Internal Audits, Sydney, Australia.
•2024 (February 28, March 6, 13): Nicotine addiction, smoking & vaping. Professional development and training. Avondale University online course.
Original Publications
Read here
- Anderson SD, Brannan JD, Trevillion L, Young IH. Lung Function and Bronchial provocation Tests for intending divers with a history of asthma. South Pacific Underwater Medical Journal 1995; 25:233-248
- Rabone SJ, Phoon WO, Anderson SD, Wan KC, Seneviratne M, Gutierrez L, Brannan JD. Hypertonic saline challenge in an adult epidemiological survey. Occupational Medicine 1996; 6:177-185
- Daviskas E, Anderson SD, Brannan JD, Chan HK, Eberl S, Bautovich G. Inhalation of dry powder mannitol increases mucociliary clearance. Eur Respir J 1997,10: 2449-2454
- Anderson SD, Brannan JD, Spring J, Spalding N, Rodwell LT, Chan KC, Gonda I, Walsh A, Clark, AR. A new method for bronchial-provocation testing in asthmatic subjects using a dry powder of mannitol. Am J Respir Crit Care Med 1997;156:758-756
- Brannan JD, Anderson SD, Koskela H, Chew N. Responsiveness to mannitol in asthmatic subjects with exercise and hyperventilation-induced asthma. Am J Respir Crit Care Med, 1998;158:1120-1126
- Subbarao P, Brannan JD, Ho B, Anderson SD, Chan H-K, Coates AL. Inhaled mannitol identifies methacholine-responsive children with active asthma. Ped Pulmonol, 2000; 29:291-298
- Brannan JD, Anderson SD, Freed R, Leuppi JD, Koskela H, Chan H-K. Nedocromil sodium inhibits responsiveness to inhaled mannitol in asthmatic subjects. Am J Respir Crit Care Med, 2000;161: 2096-2099
- Leuppi JD, Salome CM, Jenkins CR, Anderson SD, Xuan X, Marks GB, Koskela H, Brannan JD, Freed R, Andersson M, Chan HK, Woolcock AJ. Predictive markers of asthma exacerbation during stepwise dose-reduction of inhaled corticosteroids. Am J Respir Crit Care Med, 2001; 163: 406-412
- Anderson SD, Lambert S, Brannan JD, Wood RJ, Koskela H, Morton AR, Fitch KD. Laboratory protocol for exercise asthma to evaluate salbutamol given by two devices. Med Sci Sports Exer, 2001; 33: 893-900
- Brannan JD, Anderson SD, Gomes K, King GG, Chan H-K, Seale JP. Fexofenadine decreases sensitivity to and montelukast improves recovery from inhaled mannitol. Am J Respir Crit Care Med, 2001; 163: 1420-1425
- Leuppi JD, Salome CM, Jenkins CR, Koskela H, Brannan JD, Anderson SD, Andersson M, Chan HK, Woolcock AJ. Markers of airway inflammation. and airway hyperresponsiveness in patients with well-controlled asthma. Eur Respir J, 2001; 18: 444-450
- Brannan JD, Koskela H, Anderson SD, Chan HK. Budesonide reduces sensitivity and reactivity to inhaled mannitol in asthmatic subjects. Respirology, 2002; 7: 37-44
- Currie GP, Haggart K, Lee DKC, Fowler SJ, Wilson AM, Brannan JD, Anderson SD, Lipworth BJ. Effects of mediator antagonism on mannitol and adenosine monophosphate challenges. Clin Exp Allergy 2003; 33: 783-788
- Currie GP, Haggart K, Brannan JD, Lee DKC, Anderson SD, Lipworth BJ. Relationship between airway hyperresponsiveness to mannitol and adenosine monophosphate. Allergy 2003; 58: 762-766
- Brannan JD, Gulliksson M, Anderson SD, Chew N, Kumlin M. Evidence of mast cell activation and leukotriene release after mannitol inhalation Eur Respir J 2003; Sep;22: 491-6.
- Koskela HO, Hyvärinen L, Brannan JD, Anderson SD, Chan HK. Sensitivity and validity of three bronchial provocation tests to demonstrate the effect of inhaled corticosteroids in asthma. Chest 2003; 124:1341-1349.
- Koskela HO, Hyvärinen L, Brannan JD, Anderson SD, Chan HK. Responsiveness to three bronchial provocation tests in patients with asthma. Chest 2003; 124:2171-2177.
- Koskela HO, Hyvärinen L, Brannan JD, Anderson SD, Chan HK. Coughing during mannitol challenge is associated with asthma. Chest 2004; 125:1985-1992.
- Leuppi JD, Anderson SD, Brannan JD, Belousova E, Reddel HK, Rodwell LT. Questionnaire responses that predict airway response to hypertonic saline. Respiration 2005; 72:52-60
- Koskela HO, Martens R, Brannan JD, Anderson SD, Leuppi J, Chan HK. Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects. Respirology. 2005 Sep;10(4):442-8.
- Brannan JD, Anderson SD, Perry CP, Martens-Freed R, Lassig AR, Charlton B and the Aridol Study Group. The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: A phase 3 comparison study with hypertonic (4.5%) saline. Respiratory Research 2005 6:144 (9 December 2005)
- Brannan JD, Gulliksson M, Anderson SD, Chew N, Seale JP, Kumlin M, Inhibition of mast cell PGD2 release protects against mannitol-induced airway narrowing. Eur Respir J. 2006 27;944-50
- Porsbjerg C, Rasmussen L, Thomsen SF, Brannan JD, Anderson SD, Backer V. Response to mannitol in asymptomatic subjects with airway hyperresponsiveness to methacholine. Clin Exp Allergy. 2007 37;22-28
- Porsbjerg C, Brannan JD, Backer V, Anderson SD. Relationship between airway responsiveness to mannitol and methacholine to markers of airway inflammation, peak flow variability and quality of life in asthma patients. Clin Exp Allergy. 2008; 38:43-50
- O’Byrne PM, van der Linde J, Cockcroft DW, Gauvreau GM, Brannan JD, Fitzgerald M, Watson RM, Milot J, Davis B, O’Connor M, Hart L, Korducki L, Hamilton AL, Boulet LP. Prolonged bronchoprotection against inhaled methacholine by inhaled BI 1744, a long-acting beta(2)-agonist, in patients with mild asthma. J Allergy Clin Immunol. 2009 Dec;124(6):1217-21.
- Kipplelen P, Larsson J, Anderson SD, Brannan JD, Delin I, Dahlen B, Dahel S-E. Acute effects of beclamethasone on hyperpnoea-induced bronchoconstriction. Med Sci Sports Exer. 2010; 42(2):273-80
- Sue-Chu M, Brannan JD, Anderson SD, Chew N, Bjermer, L. Airway hyperresponsiveness to methacholine, adenosine 5-monophosphate, mannitol, Eucapnic voluntary hyperpnoea and field exercise challenge in elite cross country skiers. Br J Sports Med. 2010: 44;827-32
- Kippelen P, Larsson J, Anderson SD, Brannan JD, Dahlén B; Dahlén SE. Effect of sodium cromoglycate on mast cell mediators during hyperpnea in athletes. Med Sci Sports Ex. 2010: 42;1853-60
- Anderson SD, Brannan JD, Perry CP, Caillaud C, Seale JP. Sodium cromoglycate alone and in combination with montelukast on the airway response to mannitol in asthmatic subjects. J Asthma. 2010; 47;429-33
- Wallace J, D’silva L, Brannan J, Hargreave, FE, Kanaroglou, P, Nair P. Association between proximity to major roads and sputum cell counts. Can Respir J. 2011: 18(1); 13-18.
- Larsson JR, Perry CP, Anderson SD, Brannan JD, Dahlen SE, Dahlen B. The Occurrence of Refractoriness and Mast Cell Mediator Release Following Mannitol-Induced Bronchoconstriction J Appl Physiol. 2011: 110(4);1029-35
- Lemiere C, Miedinger D, Jacob V, Chaboillez S, Tremblay C, Brannan JD. Comparison of methacholine and mannitol bronchial provocation tests for assessing the impairment/disability and disease activity of workers with occupational asthma. J Allergy Clin Immunol. 2011: 129(2);555-6
- Purokivi, MK, Koskela HO, Brannan JD, Kontra KK. Cough response to isocapnic hyperpnoea of dry air and hypertonic saline are interrelated. Cough. 2011: 14;7(1):8
- Turton JA, Glasgow NJ, Brannan JD. Feasibility and acceptability of using bronchial hyperresponsiveness (BHR) to manage asthma in primary care: A pilot study. Prim Care Respir J. 2012: 21(1): 28-34
- Brannan JD, Perry CP, Anderson SD. Mannitol test results in asthmatic adults recieving inhaled corticosteroids. J Allergy Clin Immunol. 2013 131(3): 906-7
- Lundstrom SL, Yang J, Brannan JD, Haeggstrom JZ, Hammock BD, Nair P, O’Byrne P, Dahlen SE, Wheelock CE. Lipid mediator serum profiles in asthmatics signficantly shift following dietary supplementation with omega-3 fatty acids. Mol Nutr Food Res. 2013 57(8): 1378-89
- Brannan JD, Bood H, Alkhabaz A, Balgoma D, Otis J, Delin I, Dahlen B, Wheelock CE, Nair P, Dahlen SE, O’Byrne PM. The effect of omega-3 fatty acids on bronchial hyperresponsiveness, sputum eosinophilia and mast cell mediators in asthma. Chest. 2014 147(2):397-405
- Tang P, Leung S, Hor E, Ruzycki, CA, Carrigy NB, Finlay WH, Brannan JD, Devadason S, Anderson SD, Sly PD, Samnick K, Chan H-K. An apparatus to deliver mannitol powder for bronchial provocation in children under six yrs old. 2015 28(6): 452-61
- Yang MY, Verschuer J, Shi Y, Song Y, Katsifis A, Erbel S, Wong K, Brannan JD, Cai W, Finlay WH, Chan H-K. The effect of device resistance and inhalation flow rate on lung deposition of orally inhaled mannitol dry powder. Int J Pharmac. 2016 513(1-2): 294-301
- Yang MY, Ruzycki C, Verschuer J, Katsifis A, Erbel S, Wong K, Golshai L, Brannan JD, Finlay WH, Chan H-K. Examining the ability of empirical correlations to predict subject specific in vivo extrathoracic aerosol deposition during tidal breathing. Aerosol Sci Tech. 2017 51(3): 363-367
- Soo YY, FitzGerald KH, Sanini B, Kritikos B, Brannan JD, Moles RJ. Improving childcare staff management of acute asthma exacerbations – An Australian pilot study. J Asthma. 2017 54(7): 732-740
- Seccombe LM, Buddle L, Brannan JD, Peters M, Farah C. Exercise-induced bronchoconstriction with firefigher contained breathing apparatus. Med Sci Sports Exerc. 2018 50(2); 327-333
- de Menezes MB, Ferraz E, Brannan JD, Martinez EZ, Vianna EO. The efficacy and safety of mannitol challenge in a workplace setting for assessing asthma prevalence. J Asthma. 2018 in press
- Koskela H, Lake C, Wong K, Brannan JD. Cough sensitivity to mannitol challenge identifies patients with chronic cough. Eur Respir J. 2018 51(5)
- Wong H, Kjarsgaard M, Ho T, Brannan JD, Nair P. Loss of bronchoprotection to salbutamol during sputum induction with hypertonic saline: implications for asthma treatment. Allergy Asthma Clin Immunol. 2018 14:26
- Burgess A, Goon K, Brannan JD, Attia J et al., Eligibility for anti-fibrotic treatment in idopathic pulmonary fibrosis depends on the predictive equation used for pulmonary function testing. Respirology 2019 24 (10): 955-995
- Wark PAB, Cookson K, Thiruchelvam T, Brannan J, Dorhay DJ. Lumacaftor/Ivocaftor improves exercise tolerance in patients with cystic firosis and severe airflow obstruction. BMC Pulm Med 2019 19 (1): 106
- Nurmi HM, Latti AM, Brannan JD, Koskela HO. Comparison of mannitol and citric acid cough provocation tests. Respir Med. 2019 16; 158:14-20
- Zhou J, Teo, M, Ho V, Brannan JD. Prevelance and effects of gastro-oesophageal reflux during spirometry in subjects undergoing reflux assessment. PLOS One. 2020 15(2):e0229250
- Lake CD, Wong KKH, Perry CP, Koskela HO, Brannan JD. Daily inhaled corticosteroids treatment abolishes airway hyperresponsiveness to mannitol in defence and police recruits. Front Allergy. 2022 3.
- Xu M, Brannan JD, Ho V, Zhou J. Mechanism of spirometry associated gastro-esophageal reflux in individuals undergoing esophageal assessment. PLOS One. 2023 18(9): e0291445
- Leung SSY, Tsang HSL, Chan J, Kui OYH, Zeng P, Cheng YT, Cheng JW, Chan KCC, Yu M, Tang P, Brannan JD, Lam JKW, Chan HK, Li AM. Evaluation of bronchial hyperresponsiveness in asthmatic paediatric patients using mannitol challenge test – impact of body mass index. Ann Med. 2025 57(1): 2468262
Ruane LE, Leong P, Hamilton GS, Walsted ES, Lee J, Denton E, Yap E, Rogade AJ, Crawford A, Finlay PA, MacDonald MI, Brannan JD, Prior K, Petrov AA, Hull JH, Wenzel, SE, Gibson PG, Bardin PG. J Allergy Clin Immunol Pract. 2025 14: S2213-2198(25)01038-4
Guidelines Committee Publications & Review
- Weiler JW, Brannan JD, Randolph C, Hallstrand T, Parsons J, Silvers W, Storms W, Zeigler J, Bernstein DI, Blessing-Moore J, Khan D, Lang D, Nicklas RA, Oppenheimer J, Portnoy JM, Schuller D, Spector S, Tilles S, Wallace D. Exercise-induced bronconstriction Update 2016 J Allergy Clin Immunol 2016; 38:1292-1295.e36
- Price OJ, Walsted ES, Bonini M, Brannan JD, Bougault, V, Carlsen K-H, Couto, M, Kippelen, P, Moreira A, Pite H, Rukhadze M, Hull JH. Diagnosis and management of allergy and respiratory disorders in sport: An EAACI task force position paper. Allergy 2022; 77: 2909-2923
- Kanjanawasee D, Poachanukoon O, Sriprasart T, Chirakalwasan N, Saiphoklang, N, Athipongarporn A, Senavong A, Kamalaporn H, Sanguanwong N, Mitthamsiri W, Chiewachalermsri C, Seutrong B, Suwanchanratsamee A, Tantilipikorn P, Maneerattanporn M, Jaruchinda P, Kawamatawong T, Luvira V, Sombuntham P, Sompornrattanaphan M, Suwanwech T, Chotchai N, Ruxrungtham K, Boonsawat W, Brannan JD, Song WJ, Pornsuriyasak P. Chronic cough management: Practical guidelines and PICO-based evidence for screening and investigation. Asia Pac J Allergy Immunol. 2024 42(4): 305-317
- Kanjanawasee D, Poachanukoon O, Sriprasart T, Chirakalwasan N, Saiphoklang, N, Athipongarporn A, Senavong A, Kamalaporn H, Sanguanwong N, Mitthamsiri W, Chiewachalermsri C, Seutrong B, Suwanchanratsamee A, Tantilipikorn P, Maneerattanporn M, Jaruchinda P, Kawamatawong T, Luvira V, Sombuntham P, Sompornrattanaphan M, Suwanwech T, Chotchai N, Ruxrungtham K, Boonsawat W, Brannan JD, Song WJ, Pornsuriyasak P. Chronic cough management: Practical guidelines and PICO-based evidence for treatment. Asia Pac J Allergy Immunol. 2024 42(4): 318-332
Reviews & Editorials
- Anderson SD, Brannan JD. Exercise-induced asthma: Is there still a case for histamine? J Allergy Clin Immunol 2002; 109(5): 771-773
- Leuppi JD, Brannan JD, Anderson SD. Bronchial provocation tests: The rationale for using inhaled mannitol as a test for airway hyperresponsiveness. Swiss Med Wkly 2002; 132: 151-158
- Anderson SD, Brannan JD, Chan HK. Use of aerosols for bronchial provocation testing in the laboratory: where we have been and where we are going. J Aerosol Med 2002; 15(3):313-24.
- Brannan JD. A new bronchial provocation test to assess the presence and severity of asthma. RT International 2003; Fall 2003: 29-31.
- Anderson SD, Brannan JD. Methods for “Indirect” challenge tests including Exercise, Eucapnic Voluntary Hyperpnea and Hypertonic Aerosols. Clin Rev Allergy Immunol 2003; 24:27-54.
- Anderson SD, Brannan JD. Long-acting beta2-agonists and exercise-induced asthma: Lessons to guide us in the future. Ped Drugs 2004; 6:161-175
- Anderson SD, Caillaud C, Brannan JD. Beta2 agonists in exercise-induced asthma. Clin Rev Allergy Immunol. 2006; 31:163-180
- Brannan JD, Koskela H, Anderson SD. Monitoring asthma therapy using indirect bronchial provocation tests. Clin Respir J. 2007 1;3-15
- Anderson SD, Kipplelen P, Leuppi J, Brannan JD. Inhaled mannitol as a test for bronchial hyperresponsiveness. An update for 2008. La Lettre du Pneumologue • Vol. XI – n° 5 – septembre-octobre 2008
- O’Byrne PM, Gauvreau GM, Brannan JD. Provoked models of asthma: What have we learnt? Clin Exp Allergy 2008 39;181-92.
- Brannan JD, Porsbjerg C, Anderson SD. Inhaled mannitol as a test for bronchial hyperresponsiveness. Exp Rev Respir Med. 2009 3:457-68
- Anderson SD, Brannan JD. Bronchial provocation testing and collection of sputum with inhaled mannitol. Clin Exp Allergy. 2010 40;193–196.
- Brannan JD. Bronchial hyperresponsiveness in the assessment of asthma control. Chest. 2010; 138(2)(Suppl):11S–17S
- Porsbjerg C, Brannan JD. Alternatives to exercise challenge for the objective assessment of exercise-induced bronchospasm: eucapnic voluntary hyperpnoea and the osmotic challenge tests. Breathe. September 2010 7;53-63
- Brannan JD, Turton JA. The inflammatory basis of exercise-induced bronchoconstriction. Phys Sportsmed. 2010 34:67-73
- Anderson SD, Brannan JD. Bronchial provocation testing: The future. Curr Opin Allergy Clin Immunol. 2011 11(1): 39-45
- Elkins M, Brannan JD. Warm-up exercise can reduce exercise-induced bronchoconstriction. Br J Sports Med. 2013 47(10): 657-658
- Brannan JD, Lougheed MD. Airway hyperresponsiveness in asthma: mechanisms, clinical significance and treatment. Frontiers in Physiology. 2012 3; Article 460 [www.fronteirsin.org]
- Hallstrand TS, Kippelen P, Larsson J, Bougault V, van Leeuwen JC, Driessen, JM, Brannan JD. Where to from here for EIB; the unanswered questions. Immunol Allergy Clin North Am. 2013 33(3): 423-442
- Anderson SD, Perry C, Brannan JD. Inhaled mannitol as a diagnostic tool in the diagnosis and management of asthma. Clin Pulm Med. 2016 23:258-64
- Anderson SD, Daviskas E, Brannan JD, Chan HK. Repurposing excipients as active inhalation agents: The mannitol story. Adv Drug Del Review. 2018 133:45-56
- Brannan JD, Porsbjerg C. Testing for exercise-induced bronchoconstriction. Immunol Allergy Clin North Am. 2018 33(2): 215-229
- Brannan JD, Kippelen P. Bronchial provocation testing for the identification of exercise-induced bronchoconstriction. J Allergy Clin Immunol in Prac. 2020 8(7): 2156-2164
- Chang RYK, Kwok PLC, Gassabian S, Brannan JD, Koskela HO, Chan HK. Cough as an adverse effect on inhalation pharmaceuticals. Br J Pharmacol. 2020 177(18): 4096-4112
- Hengeveld VS, van der Kamp MR, Thio BJ, Brannan JD. The need for testing- The exercise challenge test to disentangle causes of childhood exertional dyspnoea. Front Pediatr. 2022 6;9:773794
- Brannan JD & Lindley MR. The Olympics have arrived: The challenge of exercise-induced bronchoconstriction in athletes. Respirology. 2024 29: 860-862
- Chiewchalermsri C, Kanjanawasee D, Saiphoklang N, Chirakalwasan N, Sriprasart T, Senavonge A, Sanguanwong N, Kamalaporn, Athipngarporn, Hachai S, Boonsawat W, Brannan JD, Song WJ, Ruxrungtham K, Poachanukoon O. Asthma Remission: A path to cure? Asia Pac J Allergy Immunol. 2025 43(4): 135-150.
Porsbjerg C, Rupani H, Brannan JD, Ueki S, Nawijn MC, Erjefält JS, Chanez P, Anderson GP Pavord I. Reframing Remission in Severe Asthma: A Conceptual Framework for Distinguishing Disease Activity Versus Damage. Lancet Respir Med. 2025 13: 1026-1040.
Book Chapters
- Anderson SD, Brannan JD. Specific Problems: Exercise-induced asthma. In Manual of Asthma Management. Eds O’Byrne PM, Thomson NC. WB Saunders London, 2001, pp. 471-486
- Anderson SD, Brannan JD, Leuppi JD, Koskela H. Monitoring airway hyper-responsiveness: Indirect stimuli – Exercise, hypertonic saline, mannitol and adenosine monophosphate. In Monitoring Asthma. Eds Gibson PG. Francis & Taylor, Boca Raton, 2005, pp. 275-323
- Brannan JD, O’Byrne PM. Mechanisms and management of exercise-induced bronchoconstriction. In Allergy Frontiers: Therapy and Prevention Editors: Pawankar R, Holgate ST, Rosenwaser LJ. Springer Japan, 2010, pp. 171-186
- Brannan JD, O’Byrne PM. Assessment of responses of the airways to therapeutic agents. In Pharmacology and Therapeutics of the Respiratory Tract, 2nd Edition Editors: Chung KF, Barnes PJ. Informa Healthcare London. 2010, pp. 100-119
- Brannan JD, Kaminski DA, Hallstrand TS. Approach to the patient with exercise-induced bronchoconstriction. In Middleton’s Allergy 9th Edition. Elsevier, pp.
- Hallstrand T, Brannan JD, Godbout K, Boulet L-P. Airway responsiveness measurement. In Pulmonary Function Tests: Principles and Practice. Springer, Switzerland, 2018, pp.171-196
- Brannan JD, Weiler J. Asthma in athletes. In Asthma and Allergy: The basics to best practices. SpringerNature Germany. 2019, pp. 401-437
- Price O, Dickenson JW, Brannan JD. Diagnosis of exercise-induced bronchoconstriction (Chapter 5). In: Complete Guide to Respiratory Care in Athletes. Taylor & Francis. 2020 pp 55-74
Protocols
- Blickisdorf T, Wood LG, Valkenborghs SR, Dixon AE, Horvat JC, Weaver NA, Yoong S, Berthon BS, Williams EJ, Brown AC, Jenkins CR, Morrissey ML, Wark PA, Wynne K, Grainge CL, El-Omar EM, Williams LM, Brannan JD, De Wang L, Wong SL, Scott HA. Personalising the management of obesity-related asthma using medical nutrition therapy and physical activity prescription: The IDEAL study protocol. Contemp Clin Trials 2025 160:108178
